Bio:
Xu Heng is a specially appointed research fellow and doctoral supervisor at Shanghai Jiao Tong University. He graduated from Kuang Yaming Honors School, Nanjing University, with a bachelor’s in physics in 2003. He graduated from Brown University with a doctorate in physics in 2010. In the same year, he worked as a post-doc fellow at Baylor College of Medicine. He was selected into the 13th Batch in China and joined the faculty of the Institute of Natural Sciences and School of Physics and Astronomy, Shanghai Jiao Tong University.
His research interest lie in biophysics and quantitative biology, with a focus on developing quantitative measurement of single cell and single molecule scale and their theoretical models to understand the quantitative laws of biological processes. He won the Career Awards at the Scientific Interface from Burroughs Wellcome Foundation. His current research focuses on: (1) Quantitative measurement and theoretical study of gene regulatory dynamics, (2) Development and application of single cell and single molecule fluorescence microscopic measurement technology.
Contact:
No. 800, Dongchuan Road, Minhang District, Shanghai, China
Room 526, Pao Yue-kong Library, Shanghai Jiao Tong University
021-54742961
Papers:
Heng Xu, Samuel O. Skinner, Anna M. Sokac,Ido Golding, “Stochastic Kinetics of Nascent RNA”, Physical Review Letters, 117, 128101 (2016).
Leonardo A. Sepúlveda, Heng Xu, Jing Zhang, Mengyu Wang, Ido Golding, “Measurement of Gene Regulation in Individual Cells Reveals Rapid Switching Between Promoter States”, Science, 351(6278), 1218 (2016).
Samuel O. Skinner, Heng Xu, Sonal N. Jaiswal, Pablo R. Freire, Thomas P. Zwaka, Ido Golding, “Single-cell analysis of transcription kinetics across the cell cycle”, Elife, 5, e12175 (2016).
Heng Xu, Leonardo A. Sepúlveda, Lauren Figard, Anna M. Sokac, Ido Golding, “Combining protein and mRNA quantification to decipher transcriptional regulation”, Nature Methods, 12(8), 739 (2015).
Arseny S. Khakhalin,David Koren, Jenny Gu,Heng Xu, Carlos D. Aizenman, “Excitation and inhibition in recurrent networks mediate collision avoidance in Xenopus tadpoles”, European Journal of Neuroscience, 40(6), 2948 (2014).
Lauren Figard, Heng Xu, Hernan Garcia, Ido Golding, Anna M. Sokac, “The plasma membrane flattens out to fuel cell surface growth during Drosophila cellularization”, Developmental Cell27(6), 648 (2013).
Samuel O. Skinner, Leonardo A. Sepúlveda, Heng Xu, Ido Golding, “Measuring mRNA copy number in individual Escherichia coli cells using single-molecule fluorescent in situ hybridization”, Nature Protocols. 8(6), 1100 (2013).
Heng Xu, Arseny S. Khakhalin, Arto V. Nurmikko, Carlos D. Aizenman, “Visual experience-dependent maturation of correlated neuronal activity patterns in a developing visual system”, Journal of Neuroscience. 31(22), 8025 (2011).
Wei Dong, Ryan H. Lee, Heng Xu, Shelley Yang, Kara G. Pratt, Vania Cao, Yoon-Kyu Song, Arto V. Nurmikko, Carlos D. Aizenman, 'Visual avoidance in Xenopus tadpoles is correlated with the maturation of visual responses in the optic tectum', Journal of Neurophysiology. 101(2), 803 (2009).
Heng Xu, Jiayi Zhang, Kristina M. Davitt, Yoon-Kyu Song, Arto V. Nurmikko, 'Application of blue-green and ultraviolet micro-LEDs to biological imaging and detection', Journal of Physics D41(9), 094013 (2008).
Heng Xu, Kristina M. Davitt, Wei Dong, Yoon-Kyu Song, William R. Patterson III, Carlos D. Aizenman, Arto V. Nurmikko, 'Combining multicore imaging fiber with matrix addressable blue/green LED arrays for spatiotemporal photonic excitation at cellular level', IEEE Journal of Selected Topics in Quantum Electronics14(1), 167 (2008).
Heng Xu, Kristina M. Davitt, Wei Dong, Yoon-Kyu Song, William R. Patterson III, Arto V. Nurmikko, Carlos D. Aizenman, “Integration of a matrix addressable blue/green LED array with multicore imaging fiber for spatiotemporal excitation in endoscopic biomedical applications”. Phys. Stat. Sol. c5(6) 2299 (2008).
Sowmya Venkataramani, Kristina M. Davitt, Heng Xu, Jiayi Zhang, Yoon-Kyu Song, Barry W. Connors, Arto V. Nurmikko, “Semiconductor ultra-violet light-emitting diodes for flash photolysis”, Journal of Neuroscience Methods160(1), 5 (2007).
Jiayi Zhang, Sowmya Venkataramani, Heng Xu, Yoon-Kyu Song, Hyun-Kon Song, G. Tayhas. R. Palmore, Justin Fallon, Arto V. Nurmikko, “Combined topographical and chemical micropatterns for templating neuronal networks”, Biomaterials27(33), 5734 (2006).
Sowmya Venkataramani, Kristina M. Davitt, Jiayi Zhang, Heng Xu, Yoon-Kyu Song, Barry W. Connors, Arto V. Nurmikko, “Compact semiconductor light-emitting diodes for dynamic imaging of neuronal circuitry”, IEEE Journal of Selected Topics in Quantum Electronics11(4), 785 (2005).
