开元体育

LiShen,Ph.D.

Howard Hughes Medical Institute

Program in Cellular and Molecular Medicine at Boston Children's Hospital

Department of Genetics at Harvard Medical School

Education

2004 - 2010, Ph.D., Cell Biology

Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences

Mentor: Dr. Gang Pei and Dr. Jiuhong Kang (Co-PI)

2000 - 2004, B.S., Biochemistry

Department for Intensive Instruction of Science and Arts, Kuang Yaming Honors School,

Nanjing University, China

ProfessionalWorkExperience

2012 –     , Postdoctoral training with Dr. Yi Zhang

Howard Hughes Medical Institute / Program in Cellular and Molecular Medicine at

Boston Children's Hospital / Department of Genetics at Harvard Medical School

2011 – 2012, Postdoctoral training with Dr. Yi Zhang

Howard Hughes Medical Institute / Lineberger Comprehensive Cancer Center at The

University of North Carolina at Chapel Hill

Publications(* co-first author)

1.   Matoba,S.,Liu,Y.,Lu,F.,Iwabuchi,K.A.,Shen,L.,Inoue,A.,andZhang,Y. (2014). Embryonic Development following Somatic Cell Nuclear Transfer Impeded by Persisting Histone Methylation. Cell 159, 884–895.

       2.   Wu,H.,Wu,X.,Shen,L.,andZhang,Y.(2014).Single-baseresolutionanalysisof

active  DNA  demethylation  using  methylase-assisted  bisulfite  sequencing.   Nat

Biotechnol. In Press.

3.   Shen,L.*,Inoue,A.*,He,J.,Liu,Y.,Lu,F.,andZhangY.(2014).Tet3andDNA Replication Mediate Demethylation of Both the Maternal and Paternal Genomes in Mouse Zygotes. Cell Stem Cell 15, 459–470.

       4.   Shen,L.*,Song,C.X.*,He,C.,Zhang,Y.(2014).MechanismandFunctionof

OxidativeReversalofDNAandRNAMethylation.  AnnuRevBiochem83,585-614.

       5.   Yamaguchi,S.,Shen,L.,Liu,Y.,Sendler,D.,andZhang,Y.(2013).RoleofTet1in

genomic imprinting erasure. Nature 504, 460-464.

6.   Lin,F.,Shen,L.,Jang,C.,Falnes,P.,andZhang,Y.(2013)Ikbkap/Elp1deficiency causes male infertility by disrupting meiotic progression. PLoS Genet 9, e1003516